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??: 2021-02-22 16:58:59 ???: ??:??


 

2?8?,??????????????????????????Nature?????????????(2019????10.717,??????13.68)????????"USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-?2 transcription",??????2018??2020???3????????????????????????????

 



????????????????,????????????????????????????????,?????????????,??????????????????????????50%????????????????,??????????????????????????????????????????????????????????????????????????KDM4C??????TGF-?2???????H3K9me3???,??TGF-?2?????,????Smad/ATM/Chk2????,??DNA????,???????????????????????????????????USP9X?KDM4C???????,USP9X????KDM4C??????????????,????TGF-?2/Smad??????????????,KDM4C??????SD70?????????????????,?????????????????,????KDM4C???????????????

??,???2020?9?8?????????????"UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance"?????,??E2/E3?????UBE2O???Myc????Mxi1????,???Mxi1 K46??????????,??????????????(ATO)??UBE2O?????,????UBE2O???,??Mxi1?????,???????????????????????????????????????,???????????????????

??????????????????????????????????????????????????????????,?????????????????????????,??????Cell Death &Differentiation (3?,2018, 2020, 2021),J Hematol Oncol (2020),Oncogene (2?,2017, 2021),Theranostics (3?,2018a, 2018b, 2020),Int J Radiat Oncol Biol Phys (????top 1??,2?,2020a, 2020b),Cancer Letters (2?,2018, 2020)???????????,??????5???,10???4?,????????????????????????(?/??)

 

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https://www.nature.com/articles/s41418-021-00740-z

https://www.nature.com/articles/s41418-020-00616-8

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